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Search Results for " complement c2 "

1

抑制剂 & 化合物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T82474	Empasiprubart ARGX-117
	Empasiprubart (ARGX-117) 是一种针对补体 C2 的人源化抑制性单克隆抗体。该抗体通过结合 C2 的 Sushi-2 结构域来阻止 C3 原转化酶的形成，进而抑制 C3 的激活，并阻断经典途径与凝集素途径的上游激活。Empasiprubart 展现出 pH 和钙依赖性的靶标结合能力，并在自身免疫性溶血性贫血以及抗体介导的器官移植排斥模型中，预防了补体介导的细胞毒性作用。

化合物

Cat.No: T82474

Synonym: ARGX-117

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01268	Complement C2 Protein, Cynomolgus, Recombinant (His) C2,CO2,Complement C2,C3/C5 conver...	Cynomolgus	HEK293 Cells
	Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC). Significantly lower C2 expression was found at HCC compared to healthy controls, and C2 was associated with TNM stages. Higher C2 expression was significantly associated with better prognosis, and multivariate analysis showed that C2 was also an independent factor for the prognosis of HCC.
TMPY-00686	Complement C2 Protein, Human, Recombinant (His) CO2,complement component 2,ARMD14	Human	HEK293 Cells
	Complement C2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.5 kDa and the accession number is P06681-1.
TMPY-03447	Complement C2 Protein, Mouse, Recombinant (His) complement component 2	Mouse	HEK293 Cells
	Complement C2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.2 kDa and the accession number is P21180-1.
TMPY-00687	Complement C2 Protein, Human, Recombinant (hFc) ARMD14,complement component 2,CO2	Human	HEK293 Cells
	Complement C2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 110 kDa and the accession number is P06681-1.
TMPH-02603	C1SB Protein, Mouse, Recombinant (His & Myc) C1sb,C1s,Gm5077,Complement C1s-1 subcomponent,C...	Mouse	E. coli
	C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
TMPJ-01064	Serpin G1 Protein, Mouse, Recombinant (His) Serping1,Plasma protease C1 inhibitor,C1 Inh,C1 esterase inh...	Mouse	HEK293 Cells
	SERPIN G1 is a member of the serpin family, The C-terminal serpin domain is similar to other serpins, and this part of C1-INH provides the inhibitory activity. SERPIN G1 is involved in the inhibition of the complement system to prevent spontaneous activation. SERPIN G1 may play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. SERPIN G1 prevents the proteolytic cleavage of later...
TMPH-03326	MASP2 Protein, Rat, Recombinant (His)	Rat	Baculovirus Insect Cells
	Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. MASP2 Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 79.2 kDa and the accession number is Q9JJS8.
TMPY-06585	C1s Protein, Human, Recombinant (His) complement component 1, s subcomponent,C1s,FLJ44757	Human	HEK293 Cells
	Complement is an integral component of the adaptive and innate immune systems and represents one of the major effector systems for the immune responses. The classical complement pathway is triggered by C1, a complex composed of the binding protein C1q and two proenzymes, C1r and C1s. Upon binding of IgG to the head of C1q, C1r undergoes autoactivation and in turn cleaves and activates C1s. C1r and C1s, the proteases responsible for activation and proteolytic activity of the C1 complex of complem...
TMPJ-00980	Complement Factor MASP3 Protein, Human, Recombinant (His) PRSS5,CRARF,Serine Protease 5,MASP1,MASP-1,Mannose-Binding L...	Human	HEK293 Cells
	MASP3 is a member of the MASPs involved in mannan-binding lectin (MBL) complement pathway. The MBL pathway is initiated by the binding of MBL to specific carbohydrate structures found on the surface of a variety of microorganisms. Activation of the complement pathway via MBL is initiated by specific MASPs. Three MASPs have been identified and all have domain structures similar to those of C1r and C1s with a heavy chain (chain A) and a light chain (chain B). Chain A is composed of CUB1, EGF, CUB2...

重组蛋白

Complement C2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01268

Species: Cynomolgus

Expression System: HEK293 Cells

Complement C2 Protein, Human, Recombinant (His)

Cat.No: TMPY-00686

Species: Human

Expression System: HEK293 Cells

Complement C2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03447

Species: Mouse

Expression System: HEK293 Cells

Complement C2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00687

Species: Human

Expression System: HEK293 Cells

C1SB Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02603

Species: Mouse

Expression System: E. coli

Serpin G1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01064

Species: Mouse

Expression System: HEK293 Cells

MASP2 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03326

Species: Rat

Expression System: Baculovirus Insect Cells

C1s Protein, Human, Recombinant (His)

Cat.No: TMPY-06585

Species: Human

Expression System: HEK293 Cells

Complement Factor MASP3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00980

Species: Human

Expression System: HEK293 Cells

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